Skip to Main Content

Gathering Unpublished Data for Compounds Detected in Biosolids

By
Charles Pittinger
Charles Pittinger
Toxicology Excellence for Risk Assessment (TERA)
Search for other works by this author on:
Andrew Maier
Andrew Maier
Toxicology Excellence for Risk Assessment (TERA)
Search for other works by this author on:
Bernard Gadagubi
Bernard Gadagubi
Toxicology Excellence for Risk Assessment (TERA)
Search for other works by this author on:
Ann Parker
Ann Parker
Toxicology Excellence for Risk Assessment (TERA)
Search for other works by this author on:
Drew McAvoy
Drew McAvoy
University of Cincinnati
Search for other works by this author on:
IWA Publishing
Volume
11
ISBN electronic:
9781780401102
Publication date:
November 2012

The Water Environment Research Foundation (WERF) commissioned a study to assemble high-quality, unpublished data on 61 trace organic chemicals (TOrC) detected in biosolids. The chemical classes of the TOrC included antibiotics, steroids, hormones, organotins, surfactants, organosiloxanes, fragrance raw materials, antimicrobials, and alcohol ethoxylates. Data on physical-chemical, environmental fate, ecotoxicology, and mammalian toxicology endpoints were compiled by queries of 48 electronic databases, and by direct communications with corporations, trade associations, water and wastewater utilities, and regulatory authorities. A substantial volume of unpublished (or recently published) experimental data was collected. Of the 61 TOrC evaluated, mammalian toxicology data and pharmacological data that can be used to derive human health benchmarks were identified for 29 of the TOrC. Empirical data for the physical-chemical, environmental fate, and ecotoxicological endpoints were less abundant; however, estimates predicted by structure-activity modeling were more readily available for these endpoints. This investigation identified numerous outstanding data gaps for the 61 TOrC. Recommendations on how to prioritize and satisfy remaining data gaps are proposed, including read-across, structure-activity relationships, and derivation approaches for toxicological benchmarks. WERF subscribers and the broader technical community can leverage the data in this study, with those compiled previously by WERF and the U.S. EPA, to prioritize further data collection needs and approaches for all chemicals evaluated to date. Consideration of commercial market trends for chemicals, in addition to exposure and hazard criteria, could help to prioritize future chemicals for further study. Ultimately, this study contributes to the goal of the WERF biosolids research program: to support sound risk characterizations for trace organic chemicals in biosolids and amended soils.

This title belongs to WERF Research Report Series.

ISBN: 9781780401102 (eBook)

Gathering Unpublished Data for Compounds Detected in Biosolids
By: Charles Pittinger, Andrew Maier, Bernard Gadagubi, Ann Parker, Drew McAvoy
DOI: https://doi.org/10.2166/9781780401102
ISBN (electronic): 9781780401102
Publisher: IWA Publishing
Published: 2012

Download citation file:


×
This content is PDF only. Please click on the PDF icon to access.
Close Modal
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close Modal
Close Modal