Gathering Unpublished Data for Compounds Detected in Biosolids
The Water Environment Research Foundation (WERF) commissioned a study to assemble high-quality, unpublished data on 61 trace organic chemicals (TOrC) detected in biosolids. The chemical classes of the TOrC included antibiotics, steroids, hormones, organotins, surfactants, organosiloxanes, fragrance raw materials, antimicrobials, and alcohol ethoxylates. Data on physical-chemical, environmental fate, ecotoxicology, and mammalian toxicology endpoints were compiled by queries of 48 electronic databases, and by direct communications with corporations, trade associations, water and wastewater utilities, and regulatory authorities. A substantial volume of unpublished (or recently published) experimental data was collected. Of the 61 TOrC evaluated, mammalian toxicology data and pharmacological data that can be used to derive human health benchmarks were identified for 29 of the TOrC. Empirical data for the physical-chemical, environmental fate, and ecotoxicological endpoints were less abundant; however, estimates predicted by structure-activity modeling were more readily available for these endpoints. This investigation identified numerous outstanding data gaps for the 61 TOrC. Recommendations on how to prioritize and satisfy remaining data gaps are proposed, including read-across, structure-activity relationships, and derivation approaches for toxicological benchmarks. WERF subscribers and the broader technical community can leverage the data in this study, with those compiled previously by WERF and the U.S. EPA, to prioritize further data collection needs and approaches for all chemicals evaluated to date. Consideration of commercial market trends for chemicals, in addition to exposure and hazard criteria, could help to prioritize future chemicals for further study. Ultimately, this study contributes to the goal of the WERF biosolids research program: to support sound risk characterizations for trace organic chemicals in biosolids and amended soils.
This title belongs to WERF Research Report Series.
ISBN: 9781780401102 (eBook)
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