This paper assesses the potential of the European Centre for Medium-Range Weather Forecasts (ECMWF) System 4 forecasts and investigates the post-processing precipitation to enhance the skill of streamflow forecasts. The investigation is based on hydrological modelling and is conducted through the case study of the Upper Hanjiang River Basin (UHRB). A semi-distributed hydrological model, TsingHua Representative Elementary Watershed (THREW), is implemented to simulate the rainfall–runoff processes, with the help of hydrological ensemble prediction system (HEPS) approach. A post-processing method, quantile mapping method, is applied to bias correct the raw precipitation forecasts. Then we evaluate the performance of raw and post-processed streamflow forecasts for the four hydrological stations along the mainstream of Hanjiang River from 2001 to 2008. The results show that the performance of the streamflow forecasts is greatly enhanced with post-processing precipitation forecasts, especially in pre-dry season (November and December), thus providing useful information for water supply management of the central route of South to North Water Diversion Project (SNWDP). The raw streamflow forecasts tend to overpredict and present similarly to forecast accuracy with the extended streamflow prediction (ESP) approach. Streamflow forecast skill is considerably improved when applying post-processing method to bias correct the ECMWF System 4 precipitation forecasts.