Mine water inrush is one of the important factors threatening safe production in mines. The accurate understanding of the mine groundwater flow field can effectively reduce the hazards of mine water inrush. Numerical simulation is an important method to study the groundwater flow field. This paper numerically simulates the groundwater seepage field in the GaoSong ore field. In order to ensure the accuracy of the numerical model, the research team completed 3,724 field fissure measurements in the study area. The fracture measurement results were analyzed using the GEOFRAC method and the whole-area fracture network data were generated. On this basis, the rock mass permeability coefficient tensor of the aquifer in the study area was calculated. The tensor calculation results are used in the numerical model of groundwater flow. After calculation, the obtained numerical model can better represent the groundwater seepage field in the study area. In addition, we designed three different numerical models for calculation, mainly to explore the influence of the tensor assignment of permeability coefficient on the calculation results of water yield of the mine. The results showed that irrational fathom tensor assignment would cause a significant deviation in calculation results.