A general circulation model (GCM) and hydrological model SWAT (Soil and Water Assessment Tool) under forcing from A1B, B1, and A2 emission scenarios by 2030 were used to assess the implications of climate change on water balance of the Gorganrood River Basin (GRB). The results of MPEH5C models and multi-scenarios indicated that monthly precipitation generally decreases while temperature increases in various parts of the basin with the magnitude of the changes in terms of different stations and scenarios. Accordingly, seasonal ET will decrease throughout the GRB over the 2020s in all seasons except in summer, where a slight increase is projected for A1B and A2 scenarios. At annual scale, average quick flow and average low flow under the B1, A1B, and A2 scenarios are projected to decrease by 7.3 to 12.0% from the historical levels. Over the ensembles of climate change scenarios, the simulations project average autumn total flow declines of ∼10% and an overall range of 6.9 to 13.2%. In summer, the components of flow at the studied basin are expected to increase under A2 and A1B scenarios but will slightly decrease under B1 scenario. The study result addresses a likelihood of inevitable future climate change.