This paper aims to study climate change impact on the hydrological extremes and projected precipitation extremes in far future (2071–2100) period in the Upper Blue Nile River basin (UBNRB). The changes in precipitation extremes were derived from the most recent AFROCORDEX climate data base projection scenarios compared to the reference period (1971–2000). The climate change impacts on the hydrological extremes were evaluated using three conceptual hydrological models: GR4 J, HBV, and HMETS; and two objective functions: NSE and LogNSE. These hydrological models are calibrated and validated in the periods 1971–2000 and 2001–2010, respectively. The results indicate that the wet/dry spell will significantly decrease/increase due to climate change in some sites of the region, while in others, there is increase/decrease in wet/dry spell but not significantly, respectively. The extreme river flow will be less attenuated and more variable in terms of magnitude, and more irregular in terms of seasonal occurrence than at present. Low flows are projected to increase most prominently for lowland sites, due to the combined effects of projected decreases in Belg and Bega precipitation, and projected increases in evapotranspiration that will reduce residual soil moisture in Bega and Belg seasons.