Coastal ecosystems are linked to socio-economic development, but simultaneously, are particularly vulnerable to anthropogenic climate change and sea level rise (SLR). Within this scope, detailed topographic data resources of Spercheios River and Maliakos Gulf coastal area in Greece, combined with information concerning the economic value of the most important sectors of the area (wetland services, land property, infrastructure, income) were employed, so as to examine the impacts of three SLR scenarios, compiled based on the most recent regional projections reviewed. Based on the results, in the case of 0.3 m, 0.6 m and 1.0 m SLR the terrestrial zone to be lost was estimated to be 6.2 km2, 18.9 km2 and 31.1 km2, respectively. For each scenario examined, wetlands comprise 68%, 41% and 39% of the total area lost, respectively, reflecting their sensitivity to even small SLR. The total economic impact of SLR was estimated to be 75.4 × 106 €, 161.7 × 106 € and 510.7 × 106 € for each scenario, respectively (3.5%, 7.5% and 23.7% of the gross domestic product of the area), 19%, 17% and 8% of which can be attributed to wetland loss. The consequences of SLR to the ecosystem services provided are indisputable, while adaptation and mitigation planning is required.