ABSTRACT
The study investigates trends and teleconnections of extreme precipitation events in the Upper Indus Basin (UIB) within the Indian region, part of the crucial geo-ecological Hindu Kush Himalayan Mountain system. Utilizing high-resolution (10km) HAR data from 2002 to 2013, we analyzed 11 indices established by the Expert Team on Climate Change Detection and Indices (ETCCDI) to observe variations in extreme precipitation at the monthly, seasonal, and annual scales. Results show an increase in dry and wet extreme precipitation frequency and intensity, increased monsoon precipitation, and a shift of winter precipitation, increasing continuous dry days. Using APHRODITE daily (0.25°) data from 1952 to 2014, continuous wavelet transform and wavelet coherence analysis indicate significant periodicities and correlations with large-scale climate anomalies such as El Niño-Southern Oscillation (ENSO) and North Atlantic Oscillation (NAO). Wavelet coherence analysis reveals that monthly extreme precipitation events significantly correlate with ENSO at 3-5 years periodicity, while annual extremes show significant coherence with NAO at 8-10 years and over 16 years periodicities. The study highlights the impact of global climate change on regional precipitation and the need for adaptive water management policies to mitigate flood risks during the rainy season and address water scarcity in the dry season.
HIGHLIGHTS
In this study, the trend analysis of extreme precipitation indices is done with high spatial resolution dataset.
Teleconnections of the indices with various climatic oscillations were identified using the wavelet transform method.
INTRODUCTION
The Fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change (IPCC) indicated that the earth's land and global average ocean temperature increased by 0.85 °C from 1880 to 2012 (IPCC 2014). This warming enhances atmosphere's moisture holding capacity that can change the frequency and intensity of the precipitation. Carbon emissions from agricultural, livestock, and industrial sectors are the main reason for extreme weather and global warming (Abbas et al. 2022a, 2022c; Elahi et al. 2024). Consequently, extreme precipitation intensity and frequency continuously increase in most parts of the world (Mei et al. 2018). Extreme precipitation events that include both high and low precipitation events will occur more frequently, as indicated by different climate model simulations (Allan & Soden 2008; Gupta et al. 2020).
Global and regional level studies indicate a change in intensity and frequency of extreme events, but these changes' characteristics differ with the study area scale (Fan et al. 2012; Ul Hasson et al. 2017). Understanding the variability and trends of extreme precipitation events is crucial for managing water resources and mitigating related risks. The Upper Indus Basin (UIB), which shares boundaries with six countries, is a crucial water source for India and Pakistan but facing significant challenges due to climate changes. The UIB's complex topography and varying altitude influence precipitation patterns within the basin and that demands a detailed study of extreme events in the region as suggested by Orr et al. (2022).
Many researchers have noticed mixed results in precipitation characteristics in the UIB after the 1950s (Malla & Arya 2023). Latif et al. (2018) analyzed variability, identified a trend, and assessed changes in annual and seasonal variability in the precipitation for the four-time series over the UIB. Bhutiyani et al. (2010) checked the trend from 1866 to 2006 and found no trend in winter precipitation and a significant increasing trend for monsoon precipitation; they also observed the influence of the North Atlantic Oscillation (NAO) in winter precipitation. Rizwan et al. (2019)) concluded an increasing trend in annual precipitation but a decreasing trend in rainy days. However, these studies often focused on the mean and total precipitation, neglecting the extreme events. In early winter, Sabin et al. (2020) found a decreasing snowfall trend in the Hindukush Himalayan mountains. Therefore, it is essential to check the variation of the extreme event on a smaller time scale with high spatial resolution data available for understanding the full impact of climate change.
The primary motivation for this study stems from the lack of comprehensive analyses on the temporal variability and teleconnections of extreme precipitation events in the UIB, particularly in the Indian region. Previous studies have mostly focused on the mean precipitation for annual and seasonal analyses with less attention on the frequency and intensity of extreme events. With these gaps, this paper has objectives for the study area to (1) firstly identify the trend of extreme precipitation at various temporal scales, (2) find the periodicity of the extreme and their coherence with the large-scale climate anomalies, and (3) assess the implications of these trends for regional water resource management.
State and variation of the extreme precipitation identification are done with the 11 indices established by the Expert Team for Climate Change Detection Indices (ETCCDI) that are used as a significant source around the globe (López-Moreno et al. 2010; Fan et al. 2012). The indices capture various aspects of extreme precipitation including frequency, intensity, and duration, offering a comprehensive understanding of changes in the UIB. There are four major categories of ETCCDI: absolute, threshold, duration, and percentiles analyzed on three temporal scales of monthly, seasonal, and annual. These index's trend significance is identified with the Mann-Kendall (MK) test, and the magnitude of this trend is checked with Sen's slope method (Mann 1945; Sen 1968). The published research categorizes extreme daily precipitation based on frequency, intensity, and amount (You et al. 2011; Madsen et al. 2014). The selection of mostly percentile thresholds in place of a fixed threshold is that the space distribution is evenly and meaningful compared with the fixed threshold (Zhang et al. 2011). Cloud bursts and flash floods are extreme events that the Indian Himalayan Region has faced in the recent past (Malla & Arya 2024; Mishra et al. 2019).
More attention is paid to the study to find the possible driving factor responsible for the changes in extreme precipitation. The study done in the past reveals that large-scale atmospheric circulation patterns are appropriate for the study of hydroclimatic records, such as the NAO, El Niño-Southern Oscillation (ENSO), and the Pacific Decadal Oscillation (PDO) (Wagesho et al. 2013). However, the specific impacts of these teleconnections on extreme precipitation in the UIB are not well understood. Many studies attempted to find the teleconnection between precipitation extremes and anomalies better to understand the underlying mechanism of extremes in regional precipitation (Ananthakrishnan & Soman 1989; Dimri et al. 2004; Han et al. 2021). Most of the methods used in the UIB use correlation coefficients between extreme and anomalies, but we should consider the characteristic of non-linearity to know about the influence of teleconnections, and for multiscale relationships, various timescales should be known (Nalley et al. 2019). There are various tools to analyze the multiscale response; after work on wavelet transform by Torrence & Compo (1998) and their update by Grinsted et al. (2004) wavelet transform became the most common tool to analyze the multiscale response (Torrence & Compo 1998; Grinsted et al. 2004; Sharma & Goyal 2020).
This paper aims to comprehensively analyze the trend in extreme precipitation and their possible driving factors, such as large-scale climate anomalies ENSO and NAO. In the paper, we have used advanced analytic techniques and the available high-resolution dataset, which is essential for spatial variability in complex terrain. The research findings are intended to inform regional water resource management policies and enhance community resilience to climate-related hazards. Additionally, we aim to contribute to a deeper understanding of the interactions between climate anomalies and extreme precipitation events.
STUDY AREA AND MATERIALS
Study area
Materials
High Asian Refined (HAR) data is the analysis data used to decadal study climate variability and atmosphere-related processes on the Tibetan plateau (Maussion et al. 2011, 2014). The data used for the trend analysis was downloaded from the TU Berlin website with a high resolution of 10 km × 10 km gridded daily precipitation data (Index of /HAR/V1/ (tu-berlin.de)), and the period of the data is from 2002 to 2013. However, it is essential to acknowledge its limitation of relatively short period restricts its ability to capture long-term trends. Despite the limitation, our selection criteria for HAR data were based on high resolution (10 km × 10 km) specifically suited for mountainous reasons. Additionally, previous studies have shown HAR data reasonable correspondence with most in situ measurements in the UIB (Pritchard et al. 2019).
Asian Precipitation Highly Resolved Observational Data Integration Towards Evaluation (APHRODITE) is a long-term continental-scale daily product that prepares precipitation data by the dense network of rain gauge data. It includes the Asia region in the south and southeast, the Himalayas, and the mountain region in the Middle East and is also majorly used in the periodicity analysis (Irannezhad et al. 2022). This study uses 0.25° × 0.25° resolution gridded data for the period 1952–2014. APHRODITE data has limitations in terms of relatively low spatial availability, but the availability for the long term makes the data suitable for the study of the periodicity and frequency analysis in the study area.
METHODOLOGY
Selection of precipitation indices
The Expert Team on Climate Change Detection and Indices (ETCCDI) has selected 11 indices to observe extreme precipitation intensity duration and frequency variations. The list is available in Supplementary Annexure 1. In the study, there are five categories of indices: (i) percentile-based indices (R95p, R99p), (ii) indices that are absolute and represent maximum and minimum values within a month, season, and year (Rx1day, Rx5day), (iii) indices based on threshold values as the number of the days when precipitation exceeds specific depths in a year (R10, R20, R25), (iv) indices based on the duration that represents a period when excessive cold, warmth, dryness, or wetness or in case of growing season period, length of mildness (CDD, CWD), and (v) total precipitation (PRCPTOT) and the intensity index (SDII) are other general indices. These indices are defined and guided by the World Meteorological Organization (WMO) (Data 2009).
Climate indices
The effects of climate anomalies (i.e., ENSO and NAO) on extreme precipitation in the UIB region impact Himalayan precipitation. For the ENSO indices, the intensity measurement on sea surface temperature anomaly in the Niño3.4 region, and the indices are named the Niño3.4 index. In the North Atlantic region, NAO is the dominant mode of changing the winter climate variability (Emori & Brown 2005). NAO is measured by the difference in normalizing sea level pressure between the low polar center and high subtropical centers; Greenland is the center and the other center of opposite signs 35° and 40° N in central latitude in the North Atlantic. The Niño3.4 and NAO are available from the National Oceanic and Atmospheric Administration (http://www.ersl.noaa.gov/psd).
Trend analysis
When it comes to examining climatic variables for trends, the application of linear tendency estimation techniques has been prevalent. Alongside the commonly used least-squares methods, the MK method is prominently employed in this study to determine the statistical significance of trends within extreme indices. Furthermore, the magnitude of these trends is evaluated using Sen's slope. A significance level of 0.05 is adopted to ascertain the significance of precipitation trends. Specifically, the slope and significance of trends are computed for the 1,332 grid cells within the study area. To capture spatial variation, the inverse distance weighting (IDW) interpolation technique is employed. While various interpolation techniques are employed globally for such data, IDW has proven to be the most effective technique for the intricate and expansive system of the UIB. As such, IDW is selected for generating accurate spatial maps within the study area.
Wavelet analysis
Continuous wavelet analysis
The continuous wavelet transform (CWT) helps extract the dominant frequencies in the hydrological time series (Mei et al. 2018). CWT examines extreme precipitation and climate anomalies in the current work to know their dominant mode of variability. CWT is applied for the APHRODITE gridded data falling in the study area to reveal the time series' variability and temporal evolution for each periodicity. It produces a wavelet spectrum with two dimensions by decomposing it into various continuous scales. Torrence & Compo (1998), Song et al. (2020), and Grinsted et al. (2004) have detailed the method.
Wavelet coherence
The cross-wavelet analysis is helpful for detecting phase spectrum but may give misleading results to the two non-normalized spectrums of the wavelet.

To balance the difference between significance and desired time–frequency features done by a smoothing operator. Significant wavelet coherence identification by the significance test based on red noise with the Monte Carlo method, which performs with the help of the MATLAB toolbox developed by Grinsted et al. (2004) and Song et al. (2020). This work is also represented the same for the above section.
RESULT AND DISCUSSION
Spatiotemporal changes of precipitation extremes
(a) Box plot diagram for the precipitation of every month and (b) spatial variation in average precipitation in mm/day increasing from green to red.
(a) Box plot diagram for the precipitation of every month and (b) spatial variation in average precipitation in mm/day increasing from green to red.
Based on the length of period
CDD and CWD spatial variation of Sen's slope with the red color indicating a decreasing trend and the blue color indicating an increasing trend and a 95% confidence level significant trend is indicated by the upward and downward arrow of opposite color.
CDD and CWD spatial variation of Sen's slope with the red color indicating a decreasing trend and the blue color indicating an increasing trend and a 95% confidence level significant trend is indicated by the upward and downward arrow of opposite color.
R95p and R99p spatial variation of Sen's slope with the red color indicating a decreasing trend and the blue color showing an increasing trend and a 95% confidence level significant trend is indicated by the upward and downward arrow of opposite color.
R95p and R99p spatial variation of Sen's slope with the red color indicating a decreasing trend and the blue color showing an increasing trend and a 95% confidence level significant trend is indicated by the upward and downward arrow of opposite color.
JJAS (monsoon) months trend analysis
Indices with their significant trend grids number out of 1,332 and their initial value of trend line as intercept and average Sen's slope
Index . | Positive count . | Negative count . | Intercept . | Slope . |
---|---|---|---|---|
R10 | 250 | 1 | 21.91 | 0.699 |
R20 | 144 | 5 | 6.71 | 0.33 |
R25 | 119 | 4 | 3.89 | 0.21 |
R95p | 266 | 0 | 305.86 | 8.38 |
R99p | 138 | 0 | 110.43 | 2.98 |
CDD | 137 | 0 | 53.16 | 1.87 |
CWD | 272 | 2 | 19.22 | 0.82 |
PRCPTOT | 364 | 0 | 705.94 | 23.68 |
SDII | 228 | 1 | 6.39 | 0.106 |
Rx1Jan | 0 | 1 | 14.95 | −0.63 |
Rx1Feb | 42 | 0 | 7.89 | 2.01 |
Rx1Mar | 0 | 73 | 8.90 | −0.42 |
Rx1Apr | 8 | 25 | 9.44 | −0.04 |
Rx1May | 96 | 2 | 9.94 | 0.34 |
Rx1Jun | 43 | 3 | 15.13 | 0.2 |
Rx1Jul | 181 | 3 | 19.14 | 0.59 |
Rx1Aug | 225 | 0 | 16.04 | 0.96 |
Rx1Sep | 17 | 1 | 16.76 | 0.125 |
Rx1Oct | 23 | 1 | 7.03 | −0.01 |
Rx1Nov | 0 | 3 | 2.32 | −0.06 |
Rx1Dec | 0 | 318 | 8.42 | −0.69 |
Rx1DJF | 0 | 0 | 20.12 | 0.535 |
Rx1MAM | 7 | 136 | 20.35 | −0.33 |
Rx1JJAS | 114 | 1 | 27.97 | 0.6686 |
Rx1ON | 9 | 1 | 8.89 | −0.15 |
Rx5Jan | 0 | 10 | 32.88 | −1.8 |
Rx5Feb | 18 | 0 | 22.49 | 2.27 |
Rx5Mar | 0 | 52 | 13.48 | −0.55 |
Rx5Apr | 10 | 32 | 15.66 | −0.06 |
Rx5May | 30 | 22 | 24.45 | 0.32 |
Rx5Jun | 61 | 1 | 15.13 | 1.14 |
Rx5Jul | 327 | 0 | 48.34 | 1.95 |
Rx5Aug | 275 | 0 | 44.57 | 2.35 |
Rx5Sep | 31 | 0 | 41.72 | 0.83 |
Rx5Oct | 7 | 12 | 17.37 | −0.11 |
Rx5Nov | 0 | 2 | 3.33 | −0.04 |
Rx5Dec | 0 | 295 | 12.22 | −0.81 |
Rx5DJF | 0 | 0 | 36.83 | 0.78 |
Rx5MAM | 18 | 158 | 35.90 | −0.28 |
Rx5JJAS | 275 | 0 | 63.22 | 2.1 |
Rx5ON | 7 | 12 | 17.37 | −0.11 |
Index . | Positive count . | Negative count . | Intercept . | Slope . |
---|---|---|---|---|
R10 | 250 | 1 | 21.91 | 0.699 |
R20 | 144 | 5 | 6.71 | 0.33 |
R25 | 119 | 4 | 3.89 | 0.21 |
R95p | 266 | 0 | 305.86 | 8.38 |
R99p | 138 | 0 | 110.43 | 2.98 |
CDD | 137 | 0 | 53.16 | 1.87 |
CWD | 272 | 2 | 19.22 | 0.82 |
PRCPTOT | 364 | 0 | 705.94 | 23.68 |
SDII | 228 | 1 | 6.39 | 0.106 |
Rx1Jan | 0 | 1 | 14.95 | −0.63 |
Rx1Feb | 42 | 0 | 7.89 | 2.01 |
Rx1Mar | 0 | 73 | 8.90 | −0.42 |
Rx1Apr | 8 | 25 | 9.44 | −0.04 |
Rx1May | 96 | 2 | 9.94 | 0.34 |
Rx1Jun | 43 | 3 | 15.13 | 0.2 |
Rx1Jul | 181 | 3 | 19.14 | 0.59 |
Rx1Aug | 225 | 0 | 16.04 | 0.96 |
Rx1Sep | 17 | 1 | 16.76 | 0.125 |
Rx1Oct | 23 | 1 | 7.03 | −0.01 |
Rx1Nov | 0 | 3 | 2.32 | −0.06 |
Rx1Dec | 0 | 318 | 8.42 | −0.69 |
Rx1DJF | 0 | 0 | 20.12 | 0.535 |
Rx1MAM | 7 | 136 | 20.35 | −0.33 |
Rx1JJAS | 114 | 1 | 27.97 | 0.6686 |
Rx1ON | 9 | 1 | 8.89 | −0.15 |
Rx5Jan | 0 | 10 | 32.88 | −1.8 |
Rx5Feb | 18 | 0 | 22.49 | 2.27 |
Rx5Mar | 0 | 52 | 13.48 | −0.55 |
Rx5Apr | 10 | 32 | 15.66 | −0.06 |
Rx5May | 30 | 22 | 24.45 | 0.32 |
Rx5Jun | 61 | 1 | 15.13 | 1.14 |
Rx5Jul | 327 | 0 | 48.34 | 1.95 |
Rx5Aug | 275 | 0 | 44.57 | 2.35 |
Rx5Sep | 31 | 0 | 41.72 | 0.83 |
Rx5Oct | 7 | 12 | 17.37 | −0.11 |
Rx5Nov | 0 | 2 | 3.33 | −0.04 |
Rx5Dec | 0 | 295 | 12.22 | −0.81 |
Rx5DJF | 0 | 0 | 36.83 | 0.78 |
Rx5MAM | 18 | 158 | 35.90 | −0.28 |
Rx5JJAS | 275 | 0 | 63.22 | 2.1 |
Rx5ON | 7 | 12 | 17.37 | −0.11 |
Sen's slope of 1-day and consecutive 5-day maximum precipitation for JJAS months and individual months of JJAS. The blue color indicates an increasing pattern and the red color as a decreasing pattern. Significant changes are indicated by the upward and downward arrow of opposite color.
Sen's slope of 1-day and consecutive 5-day maximum precipitation for JJAS months and individual months of JJAS. The blue color indicates an increasing pattern and the red color as a decreasing pattern. Significant changes are indicated by the upward and downward arrow of opposite color.
Winter (monsoon) months trend analysis
Sen's slope of 1-day and consecutive 5-day maximum precipitation for DJF months and individual months of DJF. The blue color indicates an increasing pattern and the red color as a decreasing pattern. Significant changes are indicated by the upward and downward arrow of opposite color.
Sen's slope of 1-day and consecutive 5-day maximum precipitation for DJF months and individual months of DJF. The blue color indicates an increasing pattern and the red color as a decreasing pattern. Significant changes are indicated by the upward and downward arrow of opposite color.
Based on the absolute threshold value
R10mm, R20mm, and R25mm spatial variation of Sen's slope with the red color indicating a decreasing trend and the blue color indicating an increasing trend and a 95% confidence level significant trend is indicated by the upward and downward arrow of opposite color.
R10mm, R20mm, and R25mm spatial variation of Sen's slope with the red color indicating a decreasing trend and the blue color indicating an increasing trend and a 95% confidence level significant trend is indicated by the upward and downward arrow of opposite color.
Based on other general value
PRCPTOT and SDII spatial variation of Sen's slope with the red color indicating a decreasing trend and the blue color indicating an increasing trend and a 95% confidence level significant trend is indicated by the upward and downward arrow of opposite color.
PRCPTOT and SDII spatial variation of Sen's slope with the red color indicating a decreasing trend and the blue color indicating an increasing trend and a 95% confidence level significant trend is indicated by the upward and downward arrow of opposite color.
Wavelet power spectrum of precipitation extremes and climate indices
Continuous wavelet distribution explains the relationship between extreme precipitation and climate anomalies. For the analysis of data, first, we calculated the standardized series. The difference from the mean in the original series is divided by the original series's variance. The monthly series of Rx1day monthly generates from the extreme monthly indices Rx1day. Similarly, the Rx5day monthly series is standardized and named Rx5day monthly. Rx1day yearly and Rx5day yearly are considered the extreme annual indices. To better understand yearly periodicity, R95p yearly and R99p yearly are two more indices based on percentile. The standardized 1-day (Rx1day monthly) and 5-day (Rx5day monthly) precipitation anomalies are estimated by subtracting the mean values from the Rx1day and Rx5day monthly original series and then dividing by the standard deviation for each grid. The same technique also standardizes climate anomalies. APHRODITE data are at the resolution of 0.25° × 0.25°. Climate anomalies are available every month.
Continuous Morlet wavelet spectrum of monthly and yearly precipitation extremes over and climate anomalies for the period 1952–2014. The thick black contours depict the 95% confidence level of local power relative to white noise.
Continuous Morlet wavelet spectrum of monthly and yearly precipitation extremes over and climate anomalies for the period 1952–2014. The thick black contours depict the 95% confidence level of local power relative to white noise.
Wavelet coherence between precipitation extremes and climate indices
Wavelet coherence (WTC) spectra between the monthly and yearly precipitation extremes and ENSO and NAO. Significant coherence at α = 5% are enclosed inside the thick black contour lines.
Wavelet coherence (WTC) spectra between the monthly and yearly precipitation extremes and ENSO and NAO. Significant coherence at α = 5% are enclosed inside the thick black contour lines.
CONCLUSIONS
This study provides a comprehensive analysis of the trends and teleconnections of extreme precipitation events in the UIB within the Indian region, part of the critical geo-ecological Hindu Kush Himalayan Mountain system. The extreme is defined based on percentile value, threshold value, a specific amount of precipitation, and maximum precipitation in the period 2001–2013 using HAR high-resolution (10 km × 10 km) precipitation data. The result of the monthly, seasonal, and annual trends indicates an increase in the frequency and intensity of both dry and wet extreme precipitation events, an increase in monsoon precipitation, a shift in winter precipitation, and an increase in CDD.
Using APHRODITE daily (0.25° × 0.25°) data from 1952 to 2014, we employed CWT and wavelet coherence analysis to identify significant periodicities and correlations with large-scale climate anomalies such as the ENSO and NAO. The results of indices periodicity show that percentile-based extremes have more significant periodicities than absolute indices. The coherence of monthly indices is better with the ENSO at a periodicity of 3–5 years. In comparison, coherence of the yearly extreme is significant with NAO with 8–10 years periodicity and more than 16 years periodicity. ENSO and NAO both affect the extreme precipitation in the UIB.
Our findings show an increase in CDD and increased rainfall during the monsoon period, with a decreasing pattern in early monsoon and early winter monsoon. This leads to floods in the rainy season and hydrological drought due to water scarcity in the pre-monsoon and early monsoon months. It is recommended to increase storage capacity to utilize water during the dry periods. The findings highlight the impact of global climate change on regional precipitation patterns in the UIB and underscore the necessity for adaptive water management policies. These policies are crucial for mitigating flood risks during the rainy season and addressing water scarcity during the dry season.
The findings suggest that the trends and patterns of extreme precipitation events and the influence of teleconnections point to a shift in precipitation extremes in the future. This underscores the need for future research focusing on global climate change and large atmospheric circulation (Ullah et al. 2023; Wijeratne et al. 2023). Earlier studies have shown that comparable patterns observed across various South Asian regions have been linked to climate change (Sarwar et al. 2022; Waseem et al. 2022; Rinzin et al. 2024). Consequently, there is a scope for comprehensive regional studies that utilize the latest CMIP6 dataset to extend the analysis using the ETCCDI that earlier researchers have highlighted (Abbas et al. 2022b, 2023). This approach would enhance our understanding of climate dynamics and inform future climate resilience strategies.
In summary, this study not only identifies significant trends in extreme precipitation events in the UIB but also provides a deeper understanding of the underlying mechanisms driven by large-scale climate anomalies. The insights gained from this research are essential for guiding policy decisions and improving the resilience of communities dependent on the water resources of the UIB.
FUNDING
The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.
AUTHOR CONTRIBUTIONS
A.K.: conceptualization, methodology, writing – original draft, writing – review and editing, data curation, investigation, validation, visualization, and formal analysis. M.K.M.: methodology, validation, formal analysis, review and editing, and conceptualization. D.S.A.: investigation, validation, formal analysis, supervision, writing – review and editing, conceptualization, and methodology.
DATA AVAILABILITY STATEMENT
All relevant data are included in the paper or its Supplementary Information.
CONFLICT OF INTEREST
The authors declare there is no conflict.