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Table 1

Dose–response data

ExperimentPathogenExposureResponseDosea (no. of organisms)Positive responsesNegative responsesTotal responsesResource
N. fowleri Intranasal Death 1,000 10 John & Hoppe (1990)  
10,000 10 
100,000 10 10 
1,000,000 10 10 
N. fowleri Swimming for 5 min Death 100 10 10 John & Nussbaum (1983)  
1,000 10 10 
10,000 10 
100,000 10 
1,000,000 10 
N. fowleri Swimming for 10 min Death 100 10 10 John & Nussbaum (1983)  
1,000 10 
10,000 10 
100,000 10 
N. fowleri Swimming for 20 min Death 100 10 10 John & Nussbaum (1983)  
1,000 10 
10,000 10 
100,000 10 
ExperimentPathogenExposureResponseDosea (no. of organisms)Positive responsesNegative responsesTotal responsesResource
N. fowleri Intranasal Death 1,000 10 John & Hoppe (1990)  
10,000 10 
100,000 10 10 
1,000,000 10 10 
N. fowleri Swimming for 5 min Death 100 10 10 John & Nussbaum (1983)  
1,000 10 10 
10,000 10 
100,000 10 
1,000,000 10 
N. fowleri Swimming for 10 min Death 100 10 10 John & Nussbaum (1983)  
1,000 10 
10,000 10 
100,000 10 
N. fowleri Swimming for 20 min Death 100 10 10 John & Nussbaum (1983)  
1,000 10 
10,000 10 
100,000 10 

aFor Experiment 1, the dose shown is for number of amebae administered to each mouse. For Experiments 2–4, the dose shown is the concentration of amebae/mL of swimming water.

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