The regeneration performance of the adsorbent was very important in fixed-bed experiment. Therefore, the adsorption–desorption experiments of Cr(VI)-IIP were also studied. Under the same adsorption and elution experimental conditions, the adsorbed Cr(VI) was eluted with 2 mol/L HCl, and the adsorption performance of the same batch of adsorbents filled into the dynamic column was studied. The results were shown in Table 3, In the first cycle: during the adsorption process, the t_b and t_e of the Cr(VI)-IIP in the fixed bed were 80 and 140 min, respectively, and the equilibrium adsorption amount was 10.02 mg/g. In the elution process, only 15 mL of 2 mol/L HCl was used to elute the adsorbent, and the elution efficiency was up to 98.2%. With the increase in the number of experimental cycles, it could be found that the penetration time and equilibrium time of the adsorbent in the fixed bed shorten slightly, but after five cycles, the equilibrium adsorption capacity was still up to 9.03 mg/g. In addition, after 20 mL 2 mol/L HCl was eluted, the elution efficiency was still up to 90.0%. The high elution efficiency might be determined by the mesoporous structure of the adsorbent. Large specific surface area and fast mass transfer rate enable the eluent to reach the imprinted sites quickly. Moreover, the eluent of the mobile phase in the fixed bed was more conducive to the elution of the target ion. Overall consideration, the Cr(VI)-IIP had strong regeneration ability and great potential for metal ion separation in fixed-bed experiments.