Experimental results on the uptake of Cu(II) by Ganoderma lucidum (M) and its alkali treated residue (Mc) indicated that the metal binding is a fast reaction. The pH of the sorption media affect the metal binding capacity. The equilibrium data for both M and Mc appear to fit well, the Langmuir isotherm. A simple mathematical model is developed based on adsorption equilibria and mass balance to predict the concentration of metal that can be desorbed. Disagreement between the model predicted and experimental desorption equilibria indicated that biosorption of Cu(II) by M and Mc is irreversible. EDTA and HCl are efficient eluants capable of recovering almost all the bound metal.