This article presents a methodology developed in order to identify the potential by-products of emerging chemical pollutants generated during oxidation treatments like chlorination and ozonation. As an example, the study of ozonated real river water samples spiked with estrone sulfate (E1-S) was used to evaluate the impact of ozonation on E1-S concentration and to identify the generated treatment by-products (TBPs). After a large-scale solid phase extraction, samples were analyzed by liquid chromatography coupled with high resolution mass spectrometry (HRMS) and data were processed according to a differential metabolomic-like approach to uncover the produced compounds. Four main TBPs were found. ERα-CALUX bioassays were performed to measure the estrogenic potency of samples before and after treatment. Results show that the estrogenic potency decreases drastically in drinking water with ozonation.
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Research Article|
September 14 2013
Identification of treatment by-products of the ozonation of estrone sulfate
L. Barritaud;
1Veolia Environnement Recherche et Innovation, 1 place de Turenne, 94417 Saint-Maurice, France
E-mail: [email protected]
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G. Leroy;
G. Leroy
1Veolia Environnement Recherche et Innovation, 1 place de Turenne, 94417 Saint-Maurice, France
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M. Chachignon;
M. Chachignon
1Veolia Environnement Recherche et Innovation, 1 place de Turenne, 94417 Saint-Maurice, France
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V. Ingrand;
V. Ingrand
1Veolia Environnement Recherche et Innovation, 1 place de Turenne, 94417 Saint-Maurice, France
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P. Roche;
P. Roche
2Veolia Environnement Recherche et Innovation, Chemin de la Digue, 78603 Maisons-Laffitte, France
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E. Bichon;
E. Bichon
3LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Atlanpole-La Chantrerie, BP 40706, Nantes, France and INRA, 44307 Nantes, France
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G. Gervais;
G. Gervais
3LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Atlanpole-La Chantrerie, BP 40706, Nantes, France and INRA, 44307 Nantes, France
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M. Bourgin;
M. Bourgin
3LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Atlanpole-La Chantrerie, BP 40706, Nantes, France and INRA, 44307 Nantes, France
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J. P. Antignac;
J. P. Antignac
3LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Atlanpole-La Chantrerie, BP 40706, Nantes, France and INRA, 44307 Nantes, France
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F. Monteau;
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F. Monteau
3LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Atlanpole-La Chantrerie, BP 40706, Nantes, France and INRA, 44307 Nantes, France
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B. Le Bizec
B. Le Bizec
3LUNAM Université, ONIRIS, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Atlanpole-La Chantrerie, BP 40706, Nantes, France and INRA, 44307 Nantes, France
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Water Supply (2013) 13 (5): 1302–1308.
Article history
Received:
November 10 2012
Accepted:
February 12 2013
Citation
L. Barritaud, G. Leroy, M. Chachignon, V. Ingrand, P. Roche, E. Bichon, G. Gervais, M. Bourgin, J. P. Antignac, F. Monteau, B. Le Bizec; Identification of treatment by-products of the ozonation of estrone sulfate. Water Supply 1 September 2013; 13 (5): 1302–1308. doi: https://doi.org/10.2166/ws.2013.122
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