This article presents a methodology developed in order to identify the potential by-products of emerging chemical pollutants generated during oxidation treatments like chlorination and ozonation. As an example, the study of ozonated real river water samples spiked with estrone sulfate (E1-S) was used to evaluate the impact of ozonation on E1-S concentration and to identify the generated treatment by-products (TBPs). After a large-scale solid phase extraction, samples were analyzed by liquid chromatography coupled with high resolution mass spectrometry (HRMS) and data were processed according to a differential metabolomic-like approach to uncover the produced compounds. Four main TBPs were found. ERα-CALUX bioassays were performed to measure the estrogenic potency of samples before and after treatment. Results show that the estrogenic potency decreases drastically in drinking water with ozonation.
Identification of treatment by-products of the ozonation of estrone sulfate
L. Barritaud, G. Leroy, M. Chachignon, V. Ingrand, P. Roche, E. Bichon, G. Gervais, M. Bourgin, J. P. Antignac, F. Monteau, B. Le Bizec; Identification of treatment by-products of the ozonation of estrone sulfate. Water Supply 1 September 2013; 13 (5): 1302–1308. doi: https://doi.org/10.2166/ws.2013.122
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