The toxicity response of the anaerobic treatment process can be modelled from a number of different approaches. Toxicity affects the growth rate and the effluent substrate concentration and can be modelled by competitive and uncompetitive inhibition. The biological safety factor is reduced. Most toxicants exhibit reversible toxicity, which is quite significant. Acclimation is noted to some toxicants. Molecular structure can be used to model and predict toxicity.

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