The Keelung River is one of the major tributaries of the Tansui River in Northern Taiwan. It has been heavily polluted by municipal and industrial wastewater. Based on the anaerobic CBOD and DO models, nitrification in the Keelung River and flushing time of pollutants, the calibration and verification of water quality parameters were investigated and discussed. The results of sensitivity analysis showed that K1 is the most sensitive parameter and K2 is the least sensitive to DO values in non-tidal river reaches. For the tidal reaches, the analysis indicated that Kd and K2 have larger effects on the DO values and D1 has the least effect relatively. In order to meet the water quality standards of the Keelung River, a great amount of benthic oxygen demand should be removed in addition to the secondary treatment of all point sources at downstream reaches. From the analysis of the waste load allocation, it was found that the amount of removed waste will be underestimated due to the fact that the nitrification process in the Keelung River is ignored.

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