Biodegradation of the mixed inhibitory substrates, 2,4-dichlorophenoxyacetic acid (2,4-D) and para-chloro-ortho-cresol (PCOC) was studied in aerobic batch cultures. Each substrate added beyond certain concentrations inhibited the degradation of the other. This mutual inhibition was found to be enhanced by 2,4-dichlorophenol (2,4-DCP) which is an intermediate metabolic product of 2,4-D. When 2,4-DCP accumulated to approximatelY 40 mg/l degradation of all compounds in the mixed 2,4-D and PCOC substrate system was completely inhibited. The degradation of 2,4-D and PCOC individually was also found to be inhibited by elevated concentrations of 2,4-DCP added externally, while PCOC inhibited the utilization of the intermediate.
The role of a metabolic intermediate in the biodegradation of inhibitory substrates
P. Mungkarndee, S. M. Rao Bhamidimarri, A. J. Mawson, R. Chong; The role of a metabolic intermediate in the biodegradation of inhibitory substrates. Water Sci Technol 1 November 1997; 36 (10): 27–36. doi: https://doi.org/10.2166/wst.1997.0352
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