A general methodology for the study of water quality in rivers is presented. The paper consists of four parts. In the first part the general characteristics of the area of study, which is the Beli Lom river, and its major pollution sources are presented. The effluent of the Razgrad Wastewater Treatment Plant (RWWTP) has been identified as the most significant pollution point source, due to the inadequate performance of the plant. The second part deals with data collection and processing. Four series of data have been collected, including physical, flow and water quality characteristics. In the third part a 1-d, finite-difference, second-order model is presented. In the fourth part, the model is calibrated, for the determination of its main coefficients, and is successfully verified by predicting the BOD and DO concentrations in the Beli Lom river for all series of data. Finally, the model has been applied to determine the maximum BOD and minimum DO effluent concentrations of the RWWTP, so that a minimum DO concentration is maintained throughout the river.

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