Genotoxicity analysis and hazardousness prioritization of a group of chemicals Available to Purchase

Genotoxic chemicals are increasingly being used in our daily life. 180-chemicals were screened to identify the priority of hazardousness from the point of view of their genotoxicity. Umu-test was used to evaluate the genotoxicity of these chemicals. Some chemicals exhibited high genotoxic response. A scoring algorithm was developed to evaluate the hazardousness level of these chemicals based on their genotoxicity level and four other characteristics: biodegradation probability, soil adsorption coefficient, (KOC), bioconcentration factor (BCF), Henry's Law constant (HLC). Then, these chemicals were sorted in a descending order of their hazardousness probability.