The health related risk of wastewater reclamation and reuse is usually defined by laws, rules or regulations by using only biological tools; i.e. bacteria, viruses, or other pathogens or indicators determination. Those determinations exert some influence in the costs of the mentioned practices, and it seems probable that in the near future more determinations will be required. Nevertheless, a total indication of wastewater biological quality is not given by such organisms; in fact, long-term toxicity is not detected by such means. The future of biological control of reclamation and reuse systems and the price associated to such determinations is examined through a practical application case.

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