Estrogen-like effect and cytotoxicity of chemical compounds

Katori, Y.; Ksu, Y.; Utsumi, H.

doi:10.2166/wst.2002.0763

Y. Katori;

Y. Katori

*Advanced Technology Laboratory, Kubota Corporation, 5-6 Kouyoundai, Ryuugasaki, Ibaraki pref., 301-0852 Japan

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Y. Ksu;

Y. Ksu

**Pipe Research Department, Kubota Corporation, 26 Ohamacho 2-chome, Amagasaki-shi, Hyogo pref., 660-0095 Japan

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H. Utsumi

***Graduate School of Pharmaceutical Sciences, Kyushu University, 3-3-1, Maidashi, Higashiku, Fukuoka City, Fukuoka pref., 812-8582, Japan

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Luciferase assay, cytotoxicity test and protein quantitative analysis were performed after the exposure of chemical compounds to MVLN cells that are utilized to detect the endocrine disrupting activity. These consequences indicate that the concentration is different between the estrogen receptor mediated proliferation of breast cancer cells and the estrogen receptor mediated transcription by chemical compounds.

Endocrine disrupting chemicals, bioassay, toxicity, luciferase, reporter gene assay

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Estrogen-like effect and cytotoxicity of chemical compounds

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