Investigations are presented for the development and testing of a sensor for the early stage detection and monitoring of biofilm formation. The sensor is based on the well known quartz crystal microbalance technology (QCM). The QCM detectors are integrated into the water flow system and provide continuous in-situ signals. The main objectives of the research are the evaluation of optimal operation conditions and the modification of the quartz resonator surface promoting a preferred cell attachment onto the quartz sensor surface. The miniaturization degree of the mass sensitive detector modules permits the integration into industrial plants, e.g., in order to control and ensure perfect hygienic conditions. First results of the lab study using Pseudomonas putida cultures are presented and discussed.

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