The objective of this work was to investigate electrochemical removal of nitrate from a high salinity waste stream generated by Donnan dialysis. Donnan dialysis for nitrate removal is a promising technique. It produces a distinctive composition of a high salinity waste stream of NaCl or Na2SO4 that requires a viable disposal method. The waste stream has the full anionic composition of contaminated groundwater, but the only cation is sodium. Experiments were conducted in a batch system setup. A copper cathode was chosen over brass, aluminum and graphite cathodes. A dimensionally stable anode (DSA), Ti/PbO2, was selected over a Ti/Pt anode. Electrochemical denitrification of high salinity Donnan dialysis nitrate wastes was successfully achieved, with different behavior exhibited in high salinity NaCl solution than in high salinity Na2SO4 solution. NaCl inhibited nitrate removal at high salinities while Na2SO4 did not. The maximum removals after 4 h operation in the high salinity wastes were 69 and 87% for the NaCl and Na2SO4 solutions respectively.