The current research focuses on the photocatalytic, sonocatalytic and sonophotocatalytic degradation of nigrosine dye with nitrogen-doped and undoped zinc oxide powders. The sonophotocatalytic degradation of dye was found to occur at a higher rate than during photo or sonocatalytic processes. Nitrogen-doped and undoped zinc oxide powders were synthesized by a wet chemical method. Further, Scanning electron microscopy (FESEM), Electron dispersive X-rays (EDX), X-ray diffraction (XRD), FTIR (Fourier-transform infrared spectroscopy), UV-VIS spectroscopy (UV-VIS) and Transmission electron microscopy (TEM) were used for the characterization of N doped ZnO. The kinetic study of nigrosine degradation was also studied and the results indicated that the degradation kinetics of nigrosine followed the first-order kinetics. The rate constant and the percentage of degradation was found to be highest 7.33 × 10−4 (s−1) and 92% respectively for sonophotocatalytic process after 90 min of reaction. Due to an increase in the available surface area or active site of the catalyst, a higher rate constant and degradation efficiency was observed in sonophotocatalytic system than in photocatalysis system.