A wastewater treatment plant consists of unit processes designed to achieve specific waste reduction goals. Offensive odors associated with these treatment processes are a constant source of public complaints. The purpose of this study was to statistically determine the process parameters that influence the formation of volatile sulfur compounds (VSCs) in the secondary treatment system. A statistical model was developed to relate the process parameters to the formation of VSCs in this system. The model established that F/M ratio, sludge blanket depth and SSV60 were the dominant process parameters that influenced the formation of VSCs in the secondary sedimentation basin. This model provides a useful tool for plant engineers to predict and control the VSC formation in a secondary activated sludge treatment system.